Novel polypeptide analogs and fusion proteins of a transmembrane protein, LP276, are provided. Vectors and host cells directed to these polypeptides are provided. Additionally, methods of use are provided for the treatment or prevention of allergic autoimmune diseases, type 1 diabetes, inflammation, immunodeficiencies, cancers, and infectious diseases by administering an LP276 polypeptide, analogs and fusion proteins thereof to a patient in need of such therapy.
Non-Invasive Diagnostic Method For Interstitial Cystitis And Bladder Cancer
Mary Haak-Frendscho - Madison WI Angela J. Okragly - Madison WI Andrew L. Niles - Madison WI Ricardo Saban - Madison WI
Assignee:
Promega Corporation - Madison WI
International Classification:
G01N 33574 G01N 3353
US Classification:
435 723
Abstract:
Disclosed is a method of diagnosing or monitoring interstitial cystitis or bladder cancer in a mammal. The method comprises analyzing urine of the mammal for the concentration of a urine-soluble protein selected from the group consisting of neurotrophin-3, nerve growth factor, glial cell line-derived neurotrophic factor, tryptase, and combinations thereof.
- Indianapolis IN, US Julian Davies - La Jolla CA, US Angela Jeannine Okragly - Indianapolis IN, US Chetankumar Natvarlal Patel - Fishers IN, US Stephanie Marie Truhlar - Carlsbad CA, US
Antibodies which bind and neutralize human IL-33, and methods of using same, are provided, said antibodies are useful as agents for treating conditions associated with allergic disease including treating atopic dermatitis.
Antibodies which bind and neutralize human IL-33, and methods of using same, are provided, said antibodies are useful as agents for treating conditions associated with allergic disease including treating atopic dermatitis.
Eli Lilly and Company
Senior Research Scientist
Eli Lilly and Company Oct 2016 - Jun 2018
Research Scientist
Eli Lilly and Company Oct 2000 - Sep 2016
Consultant Biologist
Promega 1994 - 2000
Scientist
Education:
The Ohio State University 1990 - 1993
Master of Science, Masters, Microbiology, Immunology
Depauw University 1986 - 1990
Bachelors, Bachelor of Arts, Biology
Skills:
Life Sciences Drug Discovery Drug Development Assay Development Lifesciences Sop Glp