Amy Katherine Solan

US Patent:

20070166350, Jul 19, 2007

Filed:

Jan 5, 2007

Appl. No.:

11/649935

Inventors:

Paul Hamilton - Cary NC, US
Daniel Kenan - Chapel Hill NC, US
Amy Solan - Durham NC, US

International Classification:

A61F 2/02
C07K 14/705
C07H 21/04
C12P 21/06

US Classification:

424423000, 530350000, 435069100, 435320100, 435325000, 536023500, 427002240

Abstract:

The present invention provides compositions and methods for an improved coating for medical devices. Provided is a biofunctional coating composition comprising at least one binding domain that has binding specificity for a metallic surface material of a medical device, and at least one binding domain that has binding specificity for cells of endothelial cell lineage. Methods for coating a metallic surface of a medical device, and for manufacturing of a medical device, comprise contacting the metallic surface to be coated with the biofunctional coating material in an amount effective to form a coating, and may further comprise contacting the coated surface with cells of endothelial cell lineage to bind the cells of endothelial cell lineage to the coated surface.