Akira Joraku

US Patent:

20060171902, Aug 3, 2006

Filed:

Feb 1, 2005

Appl. No.:

11/048097

Inventors:

Anthony Atala - Winston Salem NC, US
Akira Joraku - Winston-Salem NC, US
Christopher Sullivan - Winston-Salem NC, US
James Yoo - Winston Salem NC, US

International Classification:

A61K 8/96
A61K 35/12

US Classification:

424050000, 424093700

Abstract:

The invention is directed to compositions and methods for preparing an artificial oral tissue. The artificial oral tissue is prepared using a biocompatible substrate seeded with salivary gland cells that develop to produce a salivary gland tissue layer with a prototypal salivary system and a prototypal secretory system. The salivary gland cells proliferate, mature and differentiate into a salivary gland structure that are analogous to its in vivo counterpart.