Provided herein are novel TXNIP-modulating compounds and methods of use thereof. The TXNIP-modulating compounds may be used to enhance cellular anti-stress defense and prevent stress-induced damage to DNA, proteins and lipids. Therefore, TXNIP-modulating compounds may be used to treat or prevent a wide variety of stress-induced diseases and thus aging.
Compositions And Methods For Reversing Or Preventing Resistance Of A Cancer Cell To A Cytotoxic Agent
The present invention provides a composition and method for increasing sensitivity of a cancer cell and to reverse or prevent resistance to a cytotoxic agent. The composition includes an inhibiting agent and, optionally, a cytotoxic agent. The inhibiting agent is present in a sub-lethal dose with respect to the cancer cell in the absence of the cytotoxic agent.
Columbia University In the City of New York
Director, Precision Cancer Models Core
University of Pittsburgh Jul 2009 - Jun 2014
Assistant Professor
Albany College of Pharmacy and Health Sciences Feb 2008 - Jun 2009
Associate Director
Northwestern University Jan 2004 - Jan 2008
Associate Professor
Ichor Therapeutics, Inc. Jan 2004 - Jan 2008
Study Director and Project Lead
Education:
University of Pittsburgh 2013 - 2013
Skills:
Cancer Research Cell Biology Molecular Biology Biochemistry Cell Culture Drug Discovery Western Blotting Pcr Protein Expression Research Target Discovery Stem Cells Apoptosis Autophagy Senescence Animal Models Aging Molecular Cloning Tissue Culture Immunohistochemistry Flow Cytometry Confocal Microscopy Microscopy Fluorescence Microscopy Immunofluorescence In Vivo Cancer Project Management Organoids Pk/Pd Drug Efficacy Drug Combinations Drug Resistance Primary Cell Isolation Biobanking Preparation of Irb and Iacuc Protocols Grant Writing Reports and Publications Stem Cell Culture Patient Derived Xenografts Senolytics Sasp Health Span Strategic Planning
Aug 2009 to 2000 Assistant Professor (Research)Pharmaceutical Research Institute Albany, NY Feb 2008 to Jul 2009 Associate DirectorDepartment of Pediatrics, Northwestern University Chicago, IL 2006 to Jan 2008 Research Associate ProfessorDepartment of Pediatrics, Northwestern University Chicago, IL 2000 to 2006 Research Assistant ProfessorCancer Biology and Chemotherapy Program, CMIER, Children's Memorial Chicago, IL 1999 to 2000 Research AssociateBrain Tumor Program, CMIER, Children's Memorial Hospital Chicago, IL 1997 to 1999 Research ScientistChicago Institute for Neurosurgery Chicago, IL 1994 to 1996 Postdoctoral FellowINSERM, Lyon, France
1993 to 1994 Postdoctoral Fellow
Education:
Claude Bernard University 1993 Ph.D. in BiochemistryClaude Bernard University 1989 BiochemistryClaude Bernard University 1987 Master in BiochemistryClaude Bernard University 1986 Bachelor in Biochemistry
Skills:
Drug discovery, Drug resistance and Chemo-sensitization, Preclinical and Clinical investigations.
Youtube
A Potential Anti-Aging Therapy Dr. Abdelhadi ...
In this video, Dr. Abdelhadi Rebbaa explains potential anti-aging ther...
Duration:
24m 29s
Ask Me Anything about RepleniSENS - Dr. Abdel...
Michael Rae (Science Writer for SENS Research Foundation) asks Dr. Abd...
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Abdelhadi Reba, PhD - Ending Aging Forum 2022
Dr. Abdelhadi Rebbaa speaks at SRF's Ending Aging Forum, Sept 2022. Pr...